Role of the Acid-Sensing Ion Channel 3 in Blood Volume Control
نویسندگان
چکیده
منابع مشابه
Acid-sensing ion channels in blood volume regulation.
recise regulation of the volume and osmolarity of body fluids is fundamental to survival. A change in blood volume is sensed by cardiopulmonary baroreceptors (low-pressure receptors) that are located in the junctions between the right atrium and venae cavae and between the left atrium and pulmonary veins (Figure). Mechanical stretch of these baroreceptors due to blood volume expansion (BVE) qui...
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Cardiac afferents are sensory neurons that mediate angina, pain that occurs when the heart receives insufficient blood supply for its metabolic demand (ischemia). These neurons display enormous acid-evoked depolarizing currents, and they fire action potentials in response to extracellular acidification that accompanies myocardial ischemia. Here we show that acid-sensing ion channel 3 (ASIC3), b...
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PURPOSE Changes in extracellular pH occur in the retina and directly affect retinal activity and phototransduction. The authors analyzed the expression in rodent retina of ASIC3, a sensor of extracellular acidosis, and used ASIC3 knockout mice to explore its role in retinal function and survival. METHODS The expression and the role of ASIC3 were examined by immunolocalization and by comparing...
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Objective(s): Activation of acid-sensing ion channel 1a (ASIC1a) is responsible for tissue injury caused by acidosis in nervous systems. But its physiological and pathological roles in nucleus pulposus cells (NPCs) are unclear. The aim of this study is to investigate whether ASIC1a regulates the survival of NPCs in the acidic environment of degenerated discs. Materials and Methods: NPCs were i...
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از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2011
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-10-0607